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However, in one extensive study examining recombination rates across a diversity of studies involving multi-locus sequence typing from a variety of organisms (and therefore across a range of loci), Pérez-Losada et al. [18] estimated a wide range of recombination rates similar to those modeled here.
The range of loci per microsatellite marker (2 3) was smaller than the range of loci per RFLP marker (2 11).
This illustrates a wide and diverse range of loci containing genes that may play an important role in the development of various diseases.
Libraries of guide RNAs can be constructed that are either specific to a limited range of loci of interest or potentially unbiased and genome-wide.
Although we used a range of loci identified from the literature and from databases, we specifically screened microsatellite markers that have been previously mapped to known chromosome arms in O. mykiss (Guyomard et al. 2006; Rexroad et al. 2008).
Copy number alteration data have unique characteristics in that the copy number alteration event typically occurs across long range of loci on a chromosome rather than on each single locus or short regions.
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We tested a range of locus (100 to 1000 bp) and genotype thresholds (1 to 120%) and selected the pair of values that simultaneously minimized the mismatch error rate, minimized the probability of misscoring a presence allele (ε1.0 error rate), and maximized the number of loci retained.
Using different screens of DIYABC, (i) the three scenarios are coded and prior distributions of parameters are defined, (ii) based on previous studies (e.g. Dib et al., 1996), the GSM model is selected and prior distributions of mutation parameters are defined, (iii) motif sizes and allele ranges of loci are set and (iv) summary statistics are selected.
We then investigate the power of both one-stage method and mixed two-stage method to detect interacting disease loci for a range of two-locus epistatic models in a case control study design.
A range of resistance loci against different races of Xanthomonas oryzae pv.
"Genomics has opened up a huge range of new loci and what they do, especially in model organisms," says Roderick.
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