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The total range of lead levels measured was <0.2 μg/L to 8.6 μg/L.
Because lead levels in blood and bone were skewed toward the upper end, we used lead biomarkers in the natural log scale to improve stability over the whole range of lead levels.
9, 10 These include differences in the biological material used to measure the lead level, the timing of the samples, the range of lead levels in the samples, the timing of any specific lead exposure, and substantial differences in the methods used for statistical analysis, including choice of confounders, under- and over-control of confounders, and the use of categorical or continuous data.
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In this study, the authors aimed to examine the association of a range of blood lead levels on language skills assessed at 4, 6, 10 and 12 years of age using a prospective longitudinal design controlling for potential confounding variables including maternal vocabulary, caregiver's psychological distress and symptomatology, child's race and prenatal drug exposure.
Figure 2B shows that the plasma lead to M/P ratio relationship (indicative of relative transfer of lead) varied over the observed range of plasma lead levels.
The target value of 35 40 μg/dL was chosen because it is within the range of blood lead levels in children participating in pediatric clinical trials [ Treatment of Lead-exposed Children Trial Group (TLC) 1998].
Similar to ALAD, the range of tibia lead levels differed by genotype.
The adjusted plasma breast milk lead relationship was observed to be nonlinear with considerable variability over the range of plasma lead levels.
The range of blood lead levels was 1 68 μg/dL in the total list and 1 25 μg/dL among the 107 with paired values.
The potential magnitude and range of increases in the milk-to-blood lead ratio at maternal blood lead concentrations > 40 μg/dL are not well quantified in humans and are outside the range of blood lead levels in our current study.
The first step was to test whether the linear model of the relationship between blood lead and IQ, applied in most of the individual cohort analyses, provided a good fit over the wider range of blood lead levels represented in the pooled data.
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