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These systems currently allow high volumetric production of monoclonal recombinant antibodies in the range of grams per litre.
Yeast, as a host organism, is known for high expression yields in the range of grams per liter [ 87, 88] and the above-mentioned enzymes are likely to be expressed in soluble and active forms.
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Our current finding shows an antimicrobial activity of hydrogel containing S. edule extract on a large range of Gram negative and Gram positive multi-resistant bacteria and fungi.
Surgihoney demonstrated highly potent inhibitory and cidal activity against a wide range of Gram-positive and Gram-negative bacteria and fungi.
Pentamidine displayed synergy with antibiotics typically restricted to Gram-positive bacteria, yielding effective drug combinations with activity against a wide range of Gram-negative pathogens in vitro, and against systemic Acinetobacter baumannii infections in mice.
Analogs with up to three L-lysine substitutions showed increased potency against a range of gram-negative and gram-positive bacteria (up to 16-fold) whilst retaining low hemolytic activity.
Frenatin 2.1S and 2.2S show potent bactericidal activity against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA) and Staphylococcus epidermidis (MIC ≤16 μM) but are less active against a range of Gram-negative bacteria.
Cefprozil has in vitro activity against a broad range of gram-positive and gram-negative bacteria.
A broad range of gram-positive bacteria cause serious infections in the cancer patient with the greatest burden of disease being due to staphylococci, streptococci, and enterococci.
In the early 1990s, nitric oxide (NO) was considered as an alternative antibiotic strategy for a wide range of Gram-positive and Gram-negative bacteria [17, 18].
According to previous studies; C. diffusa exhibited good antimicrobial activity against a range of Gram-positive and Gram-negative bacteria as well as fungi [15].
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