In the future, the range of endpoints should be broadened to enable wider application in monitoring.
Tier 2 hazard characterisation is based on a sentinel 90-day rodent study with an extended range of endpoints, additional parameters being investigated case-by-case.
Currently, there is a wide range of endpoints available from predictive quantitative structure activity relationship models driven by many different computational software programs and data sources, and this is only expected to grow.
Together with published studies examining the effects of related and conventional substances, these results demonstrate that L-CNC and L-CNF are relatively non-toxic for the broad range of endpoints considered, much like their conventional cellulosic counterparts.
How these roles are interpreted depends upon whether sediment status (defined in terms of sediment quality, quantity, location and transport) is appropriate to the needs of a given endpoint; understanding and managing the dynamic interactions of sediment status on a diverse range of endpoints at the landscape or watershed scale should be the focus of sediment management.
Given the range of endpoints, the vast numbers of chemicals, the large palette of mathematical algorithms available, and the potential to use tens of thousands of chemical fragments and thousands of chemical descriptors to build a predictive model, it is clearly possible for future scientists to generate huge numbers of in silico models.
To assess the utility of these novel IDE inhibitors as chemical probes, we examined their effects on a range of endpoints relevant to insulin catabolism and signaling in cultured cells.
Thus, a range of endpoints relating to processes of care, biomedical status and self-report measures are included.
The range of endpoints is relatively broader for PCB studies while experiments addressing cancer, dermal, gastrointestinal, haematological, musculoskeletal, ocular, renal, and respiratory effects are missing in PBDE studies.
There are now a growing number of randomised controlled trials that have not shown benefits from vitamin D supplements on a wide range of endpoints.
