Sentence examples for range of downstream effects from inspiring English sources
Two attractive targets, histone deacetylase (HDAC) and topoisomerase I (Topo I), are cellular modulators that can broadly arrest cancer proliferation through a range of downstream effects.
The formation of fibronectin and integrin complex results in a range of downstream effects, including phosphorylation of FAK [50].
Exogenously applied gastrin and its precursors have a range of downstream effects on GI cancer cells.
This inhibition is likely to mediate a range of downstream effects, including anti-inflammatory and anticancerous actions.
This broad range of downstream effects that can be mediated by the CRISPR machinery provides a variety of powerful tools to fine tune the control of bacterial populations.
Somatostatin receptor signalling pathways can promote a wide range of downstream effects in GEP-NETs including inhibition of cell secretion and growth through the modulation of mitogen-activated protein kinase (MAPK) signalling or induction of apoptosis (Patel and Srikant, 1997).
"When you're regulating activity this far upstream," he said, "you have to be careful of downstream effects".
As shown in Fig. 6c, AgNPs significantly enhanced the activation of caspase-3 and the cleavage of downstream effect PARP.
Akt modulates several cellular functions including metabolism, proliferation and survival, and exerts its regulatory effects through a wide-range of downstream effectors.
KRAS and PIK3CA are located more upstream in the EGFR-signalling cascade and may, therefore, signal to a wider range of downstream signal transduction pathways and transcriptional effects.
Given the demonstrated link between network centrality and functional importance, these proteins are expected to have pervasive effects on a range of downstream molecular processes, and thus represent potential gatekeepers in the link between vitamin intake and disease.
