Further larger-scale studies, utilizing a broader range of doses and experimental conditions, are warranted.
The reactions, which included serious and sometimes deadly effects like respiratory failure, involved a range of doses and uses, many of them off label.
The drug was only in a Phase I trial — that is, a trial designed to determine the toxicity of a range of doses, not whether the drug worked.
The device can be programmed to deliver a range of doses to various depths an improvement over similar jet-injection systems that are now commercially available.
As can be seen, some of the total MICs used here are within or slightly higher than the range of doses reported as lethal to rats/mice.
We suggest that this concept (and by similar analogy MTD) is largely ambiguous since a whole range of doses applied at different frequencies can potentially fit this definition.
The drug was only in a Phase I trial that is, a trial designed to determine the toxicity of a range of doses, not whether the drug worked.
To determine how closely the loss of active behavior paralleled the blockade of brain α1-receptors, a range of doses of terazosin was injected ivt.
Previous studies demonstrated that self-administration of ethanol over this range of doses lead to a pharmacologically relevant blood ethanol concentration in rats (Roberts et al. 1999).
BACKGROUND: /st>A wide range of doses has been suggested for intrathecal clonidine, but no dose-ranging study has examined analgesic effects below 100 µg.
Locomotor activity studies were used to identify the range of doses with gross behavioral effects in rats.
