To this aim, we defined a pharmacology training set of 25 compounds containing 3 small molecules reported to directly engage AR as antagonists, and a range of compound classes targeting AR co-regulator proteins.
Because of this, numerous protocols for metabolite analysis have been developed to cover a broad range of compound classes, which are frequently characterized by the following workflow, as summarized in Figure 1: (i) material of choice, (ii) sample preparation and extraction, (iii) analytical methods, (iv) data processing and (v) data analysis and interpretation.
As well, a range of compound classes that are CDK inhibitors in P. falciparum are not effective against the human CDK enzymes tested [ 34].
The benefits of using microscale over macroscale devices for environmental agents include increased sensitivity for a range of compound classes, decreased volumes of analytic reagents, and increased throughput and potential for multiplexing.
The wide range of different compound classes requires a variety of analytical approaches and techniques, making it challenging to understand all of the different chemicals in the environment and in human and wildlife tissues.
To broaden the range of available compound classes for typical temperatures encountered in low enthalpy geothermal reservoirs, the group of carbamates was investigated.
A range of compounds representing different BVMO substrate classes were then investigated, but only bicyclic ketones were converted by 2,5-DKCMO used as crude cell extract or after purification.
Within the range of compounds produced from biofeedstocks, triglycerides form one of the largest classes, with primary applications in the food, healthcare, cosmetics and industrial lubricant sectors.
antiSMASH is the first comprehensive pipeline that can identify biosynthetic loci that cover the whole range of known secondary metabolite compound classes (polyketides, non-ribosomal peptides, terpenes, aminoglycosides, aminocoumarins, indolocarbazoles, lantibiotics, bacteriocins, nucleosides, β-lactams, butyrolactones, siderophores, melanins, and others) [ 66].
The metabolites produced by these endophytes fall within a wide range of classes of compounds that include peptides which are the focus of this review.
Moreover, while some genes, such as those that code for drug efflux pumps, contribute to resistance to a wide range of compounds, many others are drug or drug class specific.
