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Trastuzumab is also commonly used in the refractory metastatic setting in combination with a wide range of chemotherapy agents.
So far, this minireview has focused on the effects of polymorphisms in drug-metabolising enzymes in response to a range of chemotherapy drugs.
Finally, there was a wide range of chemotherapy regimens and a selection bias of chemotherapy use, since 92% of our patients were selected through a chemotherapy registry.
In the current study, the diverse range of chemotherapy administered to patients precluded correlation of miR-200 family levels and response to therapy.
Even if the management of SCLC is more consensual than that of NSCLC, several studies confirm the broad range of chemotherapy protocols prescribed (Sambrook and Girling, 2001).
For example, a change in the taste perception and nausea are unlikely to be unique to neutropenia, and may reflect common complaints for a range of chemotherapy patients.
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Previous studies have reported that free radicals are responsible for a wide range of chemotherapy-induced side effects, including liver toxicities.
Synergy of ABT-263 with a range of chemotherapies, including CPT, was recently assessed, with average CI values of 0.47, in agreement with our results.
So far it has not been shown that these model concepts are valid for a broad range of chemotherapies and schedules [ 59, 63].
Moreover, its orally bioavailable derivative, ABT-263, has shown potential clinical utility in combination therapies as it has been demonstrated to sensitize tumor types, including colorectal cancer cells, to a range of chemotherapies.
Because of the lack of innovative treatment options, the only options for most patients are salvage therapy regimens and recourse to a wide range of chemotherapies used in combination, including corticosteroids, alkylating agents, anthracyclines and cytotoxic antibiotics, antimetabolites, vinca alkaloids, and asparaginase [ 5, 9].
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