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The coupling with the suite of TOUGH simulators makes the model suitable for simulating and interpreting geophysical changes induced by a wide range of alterations in the subsurface flows, such as CO2 sequestration and geothermal exploitation.
Recent advances in molecular biology have discovered a wide range of alterations in gene expression during the process of colorectal carcinogenesis.
DOI: http://dx.doi.org/10.7554/eLife.00505.002 Genome instability can lead to a range of alterations in both the sequence and structure of chromosomes.
Recent years have seen a great expansion in the range of alterations in regulation, dosage or DNA sequence shown to disturb imprinted gene expression, and the correspondingly broad range of resultant clinical syndromes.
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The ranges of alterations in DA and GBM were 2.3%to27.8.8% and 0%to20.2%2% respectively.
Remarkably, some cancers have such a wide range and high prevalence of alterations in chromatin modifiers (ACC, ccRCC, TCC) that they may be driven primarily through epigenetic means.
Currently, genomic analysis of myeloma to cover the diverse range of alterations with prognostic impact requires fluorescence in situ hybridization (FISH), single nucleotide polymorphism arrays, and sequencing techniques, which are costly and labor intensive and require large numbers of plasma cells.
High-level expression of AtCTF7∆B appears to exert a dominant negative effect, resulting in a relatively wide range of alterations.
SFN-mediated HDAC inhibition activity causes a wide range of epigenetic alterations in many genes which are actively involved in malignant progression of cancer cells.
Similarly, recombinant cystatins expressed in Arabidopsis or tobacco were shown to induce a range of phenotype alterations in planta, including a delayed development of floral organs [ 12], a modified physiological behaviour under low temperature or light regimes [ 13], an altered protein content in leaves [ 13, 14], and a strong repression of the pathogen-inducible hypersensitive response [ 15].
Histopathological examination of CH biopsies showed a range of different alterations in the liver from mild infiltration of inflammatory cells and slight remodeling in the lobular structures of portal areas to septal fibrosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com