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Embryonic stem (ES) cells have the remarkable capacity to divide indefinitely while retaining their wide range differentiation potential, and they represent a promising source for cell transplantation therapies [1].
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Terminal differentiation-induced ncRNA (TINCR) interacts with a range of differentiation mRNAs (e.g. KRT80) to mediate their stabilization.
Examples from each genotype showed a range of differentiation between well- and moderately-differentiated HCC without an obvious tendency in the presence of either genotype.
Regulation of Rb is implicated in a broad range of differentiation events, including a general control mechanism preventing differentiated cells from re-entering the cell cycle.
ES cells must be capable of self-renewal while simultaneously retaining the capacity to commit to a wide range of differentiation lineages.
Their functions range from differentiation, chemotaxis, secondary metabolite production and virulence to adaptation to osmotic stress [ 100].
This suggests that these compounds might be effective against tumor types arising from a wide range of differentiation states.
Growing stem cells as spheres has been the initial step in a wide range of differentiation studies, as well as studies in pharmacogenetics, teratogenesis and tumourigenesis [ 32, 34- 42].
These cells exhibited a wide range of differentiation potential with robust generation of granulocytes and functional macrophages and, to a lower extent, erythrocytes and megakaryocytes.
To compensate for tissue heterogeneity, cores were taken to cover variations of histological features, such as covering range of differentiation in the same case.
Although once thought to be quiescent and terminally differentiated, we and others have shown that individual adult pancreatic cells exhibit a dynamic range in differentiation status.
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