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In one study [37], hypotonic riboflavin was used when corneal thickness was less than 400μm, and only in one article [34], 36 patients were randomized to different UV-A durations using a web-based random number generator.
The term "cluster randomization" describes a procedure whereby clusters of individuals rather than single individuals are randomized to different treatment groups, often within a nationwide registry.
Patients achieving stabilization on quetiapine were randomized to different treatment arms.
Those with categorically positive or non-positive global outcome were assessed for description of concomitant receipt of psychotherapy by subjects randomized to different pharmacotherapy treatments.
Increased circulating levels of both pro-inflammatory (IL-6) and anti-inflammatory (IL-10) mediators have been associated with poor survival in numerous studies in patients with sepsis, including patients with septic shock randomized to different fluid resuscitation strategies [4].
Seventy five percent of 20 studies that did, and only 46% of 69 studies that did not, found different outcomes in groups randomized to different pharmacotherapy interventions (p = .024).024
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It may be difficult to get investigators to agree to randomize to different methods, given that recruitment is such a major issue and a consistent cause of delay.
The women were randomized to two different prenatal interventions: They were first randomized to food consisting of a mixture of rice, lentils, molasses, and oil (two groups: early start or usual start) and then to three groups of micronutrient supplements from week 14 of gestation until delivery.
61 In another 26-week, randomized, double-dummy, placebo-controlled study, 1041 subjects were randomized to five different arms: liraglutide (0.6 mg, 1.2 mg, or 1.8 mg) once daily added to glimepiride once daily, placebo/glimepiride 2 4 mg daily, or rosiglitazone 4 mg/glimepiride combination once daily (Table 2).
Patients were randomized to 4 different methods of management: usual care, rehabilitation, ergonomics, or rehabilitation and ergonomics.
Subsequently, animals were randomized to the different treatment groups (n = 16 per group).
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