Randomized clinical trials testing moxibustion, or combined with antihypertensive drugs, against antihypertensive drugs alone were included.
Although both steroidal and nonsteroidal anti-inflammatory products were extensively tested, randomized clinical trials failed to demonstrate efficacy in AD [ 46].
Much of the published literature on the topic describes observational studies or uncontrolled programs, and there are no published, empirically tested, randomized controlled trials of validated transition programs.
Studies were limited to randomized controlled trials testing an intervention to improve adherence to guidelines that measured both a patient and adherence outcome.
To date, two randomized controlled trials tested the efficacy of SMS-based programs for smoking cessation in young people aged 16 25 years [ 8, 9].
However, neutral/negative data from two randomized controlled trials testing RhEPO to correct anemia in chronic kidney disease (CKD) were recently reported [ 2, 3].
Three of these studies were randomized controlled trials testing patient monitoring of foot skin temperature as a warning signal of an impending ulcer [ 6, 9, 10].
Interventions designed to increase perceived control may be an important aspect of HF care, but require testing in randomized trials.
However, because of the lack of randomized trials testing the different strategies of induction and maintenance, numerous controversies exist in this field.
We illustrate our methods using two randomized trials testing growth factors in febrile neutropenia.
