Nevertheless, this study is one of the few randomized studies studying EPO effects on renal function and is the only one testing the effect of EPO on inflammatory markers such as cytokines.
Measurements were included from two randomized CAP exposure studies (studies A and B) with identical exposure protocols but different cardiorespiratory outcome measures.
35– 38 Two modern randomized studies, the Intergroup study 39 and the RESORT trial, 40 have randomized patients with LTB to WW or rituximab.
In this table, among the 713 patients who were co-enrolled in another study, we present the co-enrollment study type (randomized trial, observational study), study genesis (investigator-initiated versus industry-initiated), affiliation with a research consortia, and the number of studies into which PROTECT patients were co-enrolled.
Our analysis included 3 randomized studies [165 167] and uncontrolled studies [168 171].
We relied upon observational studies, as no randomized studies comparing inter-hospital transportation of ECMO-supported patients have been published to date.
To review the literature and obtain preferences and perceptions from experts regarding the role of randomized studies (RSs) and nonrandomized studies (NRSs) in systematic reviews of intervention effects.
This recommendation is based on the results of 6 randomized studies and 8 observational studies that compared regional citrate anticoagulation with heparin anticoagulation in patients requiring continuous RRT [80, 82 87, 92, 97 103].
What we need is a lot more randomized studies, and other studies with rigorous designs, done in a lot of places, so that we can build up a large and diverse evidence base for programs that can be replicated.
"It's a small signal that immediately after the artificial salt room therapy that kids in this trial had better quality of life scores and less airway twitchiness," she says, but, "we don't have any long-term, rigorously designed studies or large, randomized studies".
