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Postwashout glucose tolerance testing, however, was only done in a subset of randomized people who completed the trial without diabetes and who then returned after the washout.
However an important number of randomized people had already died when they were contacted or refused to take part in the study.
The analysis excluded 335 of the 1,004 randomized people: 25 had no baseline ECG, 99 had no ECG at 2 years, 82 withdrew from study, 16 died during follow-up (7 were adjudicated as cardiovascular deaths), ECGs for four individuals were not available for unknown reasons, and 109 ECGs were not suitable for 12-lead analysis.
In one trial that randomized people with Type 2 diabetes and existing cardiovascular disease to very intensive management targeting HbA1c < 6.5% (48 mmol/mol), mortality was higher in the intensive group, driven by deaths in those people who failed to show HbA1c improvement as treatment was intensified [ 31].
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In fact, two randomized studies comparing people who used triclosan hand soaps with people who used plain soaps found no evidence that triclosan contributed to bacteria resistance.
Left ventricular mass (LVM) is a widely used surrogate end point in randomized trials involving people with chronic kidney disease (CKD) because treatment-induced LVM reductions are assumed to lower cardiovascular risk.
The only way to sort out cause and effect is to do a randomized trial, moving people around between neighborhoods and tracking their health over several years.
In 15 randomized, controlled trials, people in need of social services either encountered the standard application process or received a psychological nudge, in which the information was presented slightly differently a postcard reminded them of deadlines, for example, or one choice was made easier than another.
In this double blind, placebo controlled randomized trial in people with metabolic syndrome, daily consumption of a food supplement combining RYR and olive fruit extract resulted in a 24% decrease of LDL concentrations, accompanied by a smaller but significant decrease of total CHOL, apoB, and TG.
He called Dr. Gotzsche's harshness toward other people's randomized trial data "unscientific and even bizarre".
But more recent, randomized studies that followed people for months and in some cases years suggest that the effect is negligible.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com