A randomized nonblinded prospective trial of adult patients undergoing procedural sedation for painful procedures in the ED was made.
To contribute to closing this gap, the Italian Society of Diabetology is conducting the Thiazolidinediones or Sulfonylureas and Cardiovascular Accidents Intervention Trial (TOSCA.IT), a randomized, parallel-group, nonblinded trial designed to compare the impact on CVD of pioglitazone versus sulfonylureas as add-on drugs in patients inadequately controlled with metformin.
The design is a multicenter, controlled, cluster-randomized, nonblinded clinical trial to evaluate the effectiveness of an intervention related to the prescription of cholesterol-lowering drugs in primary prevention, compared to usual clinical practice.
Design: Prospective, randomized, nonblinded clinical trial.
Sainio and colleagues randomized 60 patients with alcoholic necrotizing pancreatitis to receive cefuroxime versus no antibiotic treatment in a nonblinded trial [ 2].
Nevertheless, the current study does have several limitations, including a very small number of subjects, a nonblinded trial design, and a small but potentially important HbA1c difference favoring exenatide (6).
The ACCORD blood pressure trial was a nonblinded trial; patients in the standard-therapy groups had a lower exposure to antihypertensive drugs (2.1) as compared to the intensive-therapy group (3.4).
This prospective, randomized, nonblinded, single-center trial evaluates the safety and effectiveness of TVC (intervention), compared with NC (control) in female patients with symptomatic cholecystolithiasis.
The few prospective studies that exist investigating antibiotic use in severe pancreatitis have been nonblinded trials with small patient populations [ 1, 2].
JPAD was a prospective, nonblinded, randomized clinical trial; event adjudication was done by an independent end point committee blinded to treatment assignment.
