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The WHI, the largest of several randomized intervention trials to examine the issue, essentially said: au contraire.
We review randomized intervention trials that investigated effects of either industrial trans fatty acids, or conjugated linoleic acid, or other ruminant trans fatty acids on the LDL to HDL cholesterol ratio, and on LDL and HDL cholesterol concentrations.
However, conflicting data has been generated from two recent large randomized intervention trials.
Additional data from randomized intervention trials are needed to confirm this potential benefit.
Similarly, randomized intervention trials for post-partum weight loss have been limited in their effectiveness [ 24, 27].
As yet, no randomized intervention trials specifically designed to test the effect of vitamin D supplementation on incident diabetes in healthy individuals have been published.
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Methods: From 2009 until 2013 a randomized intervention trial was performed in three university medical centres and 12 teaching hospitals in the Netherlands [2].
The only randomized intervention trial was evaluated separately (8).
Baby Smiles was a five-year, four-site randomized intervention trial with a 2 × 2 factorial design.
Examining natural progression is not always possible with an intervention design and we feel that additional research would be helpful before developing an evidence-based, randomized intervention trial.
The randomized intervention trial directly measures the impact of drinking water on diarrhea and compares the incidence of GI illness between intervention and control subjects.
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