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Nested randomized intervention studies could further identify successful local prevention programs (24).
The beneficial effects of statins on DN progression also remain unclear due to the lack of prospective, randomized intervention studies.
The sample size was calculated as required for the cluster randomized intervention studies to be also conducted during phase II of this research project.
Randomized intervention studies directed at physicians and/or patients at high risk of osteoporosis-related fractures conducted by Solomon and colleagues [ 33, 34] and by Elston Lafata and colleagues [ 35] found that screening and treatment rates were either unaffected [ 33, 34] or improved by less than 10% [ 35].
One should take into account that no randomized intervention studies have reported equity of care results.
Paavola et al. (2002) noted that few randomized intervention studies had a follow-up longer than twelve months.
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12. Elhayany A, Lustman A, Abel R, Attal-Singer J, Vinker S. A low carbohydrate Mediterranean diet improves cardiovascular risk factors and diabetes control among overweight patients with type 2 diabetes mellitus: a 1-year prospective randomized intervention study.
In a PHC randomized intervention study in southern Vietnam, the presumptive diagnoses for AUF patients were recorded and confirmed by serology on paired (acute and convalescence) sera.
Jokhio and colleagues, in their large cluster randomized intervention study on prevention of perinatal mortality in Pakistan, reported a 20% reduction in perinatal death when TBA were trained and provided with disposable delivery kits[ 7].
In Northern Germany, the Kiel Obesity Prevention Study (KOPS), a cluster randomized intervention study, has been performed between 1996 and 2001 by the Institute of Human Nutrition and Food Science of the Christian-Albrechts-University of Kiel in the context of the school entry health examination (SEH; 12,254 children participated in the SEHs during these years) (Plachta-Danielzik et al. 2012b).
Study design was limited to randomized controlled trials (RCTs) and non-randomized intervention studies [12].
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