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To map the current status of head-to-head comparative randomized evidence and to assess whether funding may impact on trial design and results.
To estimate the number of randomized controlled trials (RCTs) published annually that evaluate the impact of diagnostic tests on patient outcomes to gauge the extent of available randomized evidence assessing the effectiveness of diagnostic tests.
We identified weak concordance between the PDR and RCTs (weighted κ=0.31; P<.The).The RCTs offer substantial evidence about the common effects of drugs on the risk of sleep disturbance; currently, prescription information only partially agrees with the available randomized evidence.
High-quality randomized evidence is lacking for the use of inotropes for other heart failure indications, such as for acute decompensations or as a "bridge to transplant". CONCLUSIONS: On the basis of the available evidence, the routine use of inotropes as heart failure therapy is not indicated in either the acute or chronic setting.
Similarly, randomized evidence failed to demonstrate a clinical impact.
Case reports suggest NSAIDS may offer symptomatic relief, however randomized evidence for this is lacking.
Similar(13)
Migraine is very common in school-aged children, but despite a number of pharmacological and non-pharmacological options for prophylaxis, randomized controlled evidence in children is small.
Currently available randomized trial evidence suggests that hyperoncotic albumin solutions may reduce the incidence of AKI and death.
In some clinical indications, randomized trial evidence has suggested certain benefits of hyperoncotic albumin such as reductions in morbidity, renal impairment and edema.
Significant randomized trial evidence supports creating fall prevention programs for community-dwelling older adults, but adoption in routine care has been limited.
For the 160 recommendations that were randomized for evidence review, The Dr Oz Show recommended consulting a healthcare professional 9% (7/80) of the time compared with 33% (26/80) of the time on The Doctors.
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