Subjects were randomized by center, age, and diabetes treatment to twice-a-week supervised mixed (aerobic and resistance) training plus exercise counseling (exercise [EXE] group) versus counseling alone as part of standard care (control [CON] group) for 12 months.
Samples were randomized by sex and age such that biological replicates of the same group were not hybridized to the same slide.
Participants were randomized, stratified by age, diabetes status, and race to one of four treatment assignments: OM 40/AML 10/HCTZ 25 mg, OM 40/AML 10 mg, OM 40/HCTZ 25 mg, or AML 10/HCTZ 25 mg.
Participants were randomized by strata of sex, age (older or younger than the median), BMI (below or above the median), history of coronary heart disease (yes/no), type 2 diabetes (yes/no), and current use of statins (none, <1 year, ≥1 year).
The participants were randomized by strata of sex, age (below or above the median), BMI (below or above the median), history of coronary heart disease (yes/no), type 2 diabetes mellitus (yes/no), and current use of statins (none, <1 year, or ≥1 year).
Sixty-seven patients (40 girls, mean age ± SD 11.3 ± 1.1, 27 boys mean age ± SD 11.4 ± 0.9) with eighty-nine PDCs were randomized by block randomization method with allocation concealment in consecutive numbers of sealed envelopes.
The order of breathing modes was randomized by computer randomization.
Within each age category, mice were randomized by body weight; half were maintained on control diet and half were switched to MR diet containing 0.172% methionine (Dyets).
