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RAs will be present in the ED for each randomised shift, and will aim to enrol consecutive patients presenting to the ED.
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"We use both randomised pitch shifting and actual different samples between each firing.
[ 13] Contamination of members of the control group in an individual randomised trial tends to shift their outcome in the same direction as the outcome in the intervention group.
Participants Fifteen clinics all implementing decentralisation and task shifting were randomised.
If during a randomised trial, a systematic response shift of a clinically important magnitude occurred due to the nature of an intervention, inappropriate conclusions regarding effect on health-related quality of life may be drawn.
Despite a paucity of high-quality randomised studies to direct this shift, the dramatic results seen with these pragmatic approaches have been persuasive, and multimodality treatment of liver and lung metastases is now the standard of care in many institutions (Tampellini et al, 2012; Nordlinger et al, 2013).
Patients who experience subacute worsening of POEMS syndrome with subacute capillary leak-like symptoms (ie, 5 kg/month of weight gain or pleural effusion increase) or evident deterioration of neuropathy (ie, increase in the total score on the overall neuropathy limitation scale of >2) will promptly be shifted from the randomised comparative period to the long-term safety period.
Adjusted for differences between study arms, the estimated odds ratio was 0.37 (0.17,0.77), representing a shift towards the estimate for the randomised studies alone.
This shift has been prompted by results from randomised clinical trials that have clearly demonstrated breast-conserving surgery followed by radiotherapy is equivalent to more radical procedures in terms of local control and overall survival [ 1].
In this systematic review, we evaluated the evidence from published randomised controlled trials (RCTs) for the use of task-shifting strategies for CVD risk reduction in LMICs.
To evaluate evidence from published randomised controlled trials (RCTs) for the use of task-shifting strategies for cardiovascular disease (CVD) risk reduction in low-income and middle-income countries (LMICs).
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