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This questionnaire was part of a cluster randomised quality improvement interventions in chronic kidney disease (QICKD; ISRCTN56023731).
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Seven studies evaluated social cognitive theory-based interventions, including 2 high-quality randomised controlled trials, 21 29 2 high quality controlled trials 28 30 and 3 low quality controlled trial.
[ Based on moderate quality randomised controlled trials in people with depression and chronic physical health problems and on extrapolation from moderate quality randomised controlled trials in people with depression] For people who first present with severe depression and a chronic physical health problem, consider offering individual CBT combined with antidepressant medication.
However, although placebos are an important component in randomised trials, their quality is often left unquestioned.
Improved strategies are still needed for cartilage and the best cost-effective treatment should be identified with more rigorous prospective, with high quality randomised clinical trials (Vilela et al. 2015).
Chemotherapy seems to improve symptoms control, even if randomised studies with quality of life as first endpoint are lacking and often chemotherapy toxicity compromises the frail cost/benefit ratio.
Although it may not be so easy, a superior research and funding mind-set seems to be necessary to encourage academic scientists and clinicians to execute studies that seek long-term outcomes, and high quality randomised clinical trials that take many years and consume a tremendous amount of money but yield only one paper eventually.
In addition, large-scale quality randomised studies are desperately needed to guide clinicians.
This belief still has to be verified by high quality randomised clinical trials, which are still lacking in literature.
There remains a need for more, high quality, randomised control trials of therapeutic hypothermia after traumatic brain injury.
20 Since publication of that review, 20 data from two relatively large and high quality randomised controlled trials (funded by the NHS) in the UK have been published.
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