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Efficacy analyses were conducted in the randomised population according to the arm to which patients were assigned at randomisation; response rate was assessed in the subset of these patients who had measurable disease at baseline.
Demographics of the randomised population are presented at Table 1.
We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI.
However, the response rate analysis was based on only three quarters of the randomised population.
In the randomised population, the incidence of SAEs was comparable between treatment arms (standard dose 31% vs dose escalation 28%).
The personal and clinical characteristics of the randomised population were well matched among the groups (table 1).
Similar(32)
A randomised, population-based study with a large sample size will be required to confirm our findings.
A major strength of this study is that the data comes from a randomised population-based sample of men and women in Sweden.
In conclusion, this randomised population-based trial provides important data on the test characteristics of FIT screening at different cut-off values.
As the current results derive from a randomised population-based study analysed by intention to screen, most of the biases are avoided.
We conducted a randomised population-based trial to determine test characteristics of FIT (OC-Sensor micro, Eiken, Japan) screening at different cut-off levels and compare these with guaiac-based faecal occult blood test (gFOBT) screening in an average risk population.
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