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Network motifs must meet the following criteria[ 18]: (i) The probability that the motif appears in a randomised network in an equal or greater number of times than in the real network is smaller than p = 0.01.
Network anti-motifs meet the following criteria, as defined here: (i) The probability that the anti-motif appears in a real network in a frequency equal to or greater than the number of times it appears in the randomised network is less than p = 0.01.
Similar(58)
Normalisation of DDCs is usually based on comparison against appropriate randomised networks (null models).
The simplified network was compared against randomised networks with the same number of nodes and edges and the subgraphs that occurred significantly more often than in the random network were considered important.
(ii) The number of appearances in the real network is significantly lower than in the randomised networks: Nestimated - Nobserved > 0.1 Nobserved.
This avoids detecting as motifs common connections that differ only slightly between Nobserved and Nestimated, but have a narrow distribution in the randomised networks.
This avoids detecting as anti-motifs common connections that only have a slight difference between Nobserved and Nestimated but have a narrow distribution in the randomised networks.
(ii) The number of times the motif appears in the real network with distinct sets of nodes is at least U = 2. (iii) The number of appearances in the real network is significantly larger than in the randomised networks: Nobserved - Nestimated > 0.1 Nestimated.
We used wmfinder, version 10.06 tool (available on request from [ 26]) to compare each observed Two-node or Three-node connections to their expected frequency obtained by examining 1000 randomised networks made by randomly switching the edges of the real network among the different nodes.
Supplementary table 6 presents estimated rate ratios of all possible comparisons from conventional meta-analysis of direct randomised comparisons and network meta-analysis; estimates from network and conventional meta-analysis, where available, were compatible.
METHODS AND RESULTS: A prospective economic evaluation piggy-backed onto the randomised controlled Interdisciplinary Network for Heart Failure (INH) Study weighted costs of the intervention HeartNetCare -HF™ (HNC) regarding effectiveness, mortality and quality-adjusted life years (QALYs).
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