The subsequent MRC RT01 trial [ 39] randomised 862 men to the same fractionation regimens and found that at 6 months after radiotherapy grade 2 or higher toxicity was low [ 28].
A recent systematic review 4 found that only 27% of participants in randomised trials were men.
Dietary counselling, similar to the advice given to the intervention group in our study but which extended over a 3-year interval, has been shown to reduce ICAM and tPAag concentrations in a randomised trial of men aged 65 75 years.
We sought completed randomised trials in men with localised prostate cancer that had compared two or more of the following interventions (as primary treatment, with or without the same adjuvant therapy in all arms): prostatectomy, radiotherapy including brachytherapy, cryotherapy, high-intensity focused ultrasound (HIFU) and observational management.
The design employs four randomised groups of men in order to distinguish the effects of Prosdex from two other possible effects: format (electronic versus written), and the Hawthorne effect, specifically the effect that participating in a clinical trial could have on subsequent PSA uptake.
In addition, the results from a randomised controlled trial in men demonstrated the efficacy of the quadrivalent HPV vaccine against external genital lesions in men, including genital warts and anal precancerous lesions [16, 17].
182 participants with COPD (age 68±8 years, 62% moderate COPD and 53% men) were randomised (HM=90 and UC=92).
The Cancer Research UK funded PATCH study (Prostate Adenocarcinoma TransCutaneous Hormone) compares LHRHa with transdermal oestrogen patches in a phase II randomised clinical trial of men with locally advanced or metastatic prostate cancer.
Randomised trials comparing the efficacy and safety of different primary treatments (48 papers from 21 randomised trials included 7350 men). 2 reviewers independently extracted data and assessed risk of bias.
The NORCCAP-trial is a large randomised trial in which men and women (1 1), aged 50 64, living in Telemark (mixed rural and urban population) or Oslo (urban population) (1 1) were randomly drawn from the national population registry to be invited to have a colorectal cancer screening examination.
