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Here, we demonstrate that selecting for improved folding stability is a valid approach to improving the solubility and folding stability of a non-biological protein from random sequence origin.
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The current study brings out three major lines of corroborating evidence for the random-sequence origin of protein coding split-genes.
We tested whether the genome sequence and ORF properties of these diverse species corroborate or disprove the random-sequence origin of the split-gene (ROSG) model.
The initial analysis based on the random-sequence origin of protein-coding genes [27], [30], [31] with limited data provided evidence that the DNA of eukaryotic organisms may be highly random.
As a concrete example, it is common practice in SELEX experiments to align RNA aptamer sequences (with themselves and with natural sequences) in order to find common motifs, in spite of the fact that the aptamer RNAs may be known to each have independent origins from a random sequence library [ 112].
But music is rarely just a random sequence of these 12 notes.
On top of the bridge's two towers, red lights flashed in random sequence, jarringly.
It can, they say, be less a meal than a random sequence of events.
Actually, a truly random sequence of numbers has not yet been discovered".
random sequence with common density ƒ.
A random sequence, then, is not a significant sequence.
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