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Patients can enter more than one random pathways.
We used the random pathways to compute a background distribution of correlations.
The selected J pathways were random pathways that either had <300 SNPs or >700 SNPs.
We cross-validated both the GenMAPP pathways and the random pathways and plotted the rank-ratios.
Tertiary units (households) and individual units were selected using a combination of random pathways and quotas for sex and age.
For example, 15 times more query genes from GenMAPP pathways were in the top 1%, with rank-ratio less than 0.01, than from random pathways.
Similar(43)
In the absence of heterotropic nucleotide regulators the enzyme follows a random pathway of substrate addition but saturation with ADP enforces a compulsory-order mechanism in which glutamate is the leading substrate.
For each metabolic pathway, the number of genes, N, was rounded to the nearest five and the random distribution from the appropriate dataset and pathway size utilized to test if that pathways VMR or CV differed significantly from a random "pathway" of similar size.
The classifier based on this procedure was designated as the random pathway feature (RPF) method.
We calculated the score for each random pathway using the A m method previously described using the Cooper et al. data.
High scores were associated with poor prognosis in each of the studies, and were also significant compared with a background of random pathway permutations.
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