Exact(6)
The interconnected void space produced by random module packing created flow channels that were lined with endothelial cells.
While the ring lattice remains unchanged, the size of the random module increases throughout the series, such that its proportion of the full network grows gradually.
None of the random module enrichment P-values exceeded the P-value for the real turquoise module, indicating that this enrichment is specific to the BMD GWAS network.
To compute the significant of finding specific COGs functional modules, we generated 10,000 random module sets of the same size, and counted the number of times we found each COGs module in each randomized network.
Thereafter, the participating schools will be subjected to stratified randomization according to the baseline prevalence of tobacco use at each school by the "random" module, and the option separate strata of PEPI (version 4.0, Sagebrush Press).
To compute the significant of finding specific COGs modules, a p-value for each module was calculated based on the distribution of 10,000 random module sets of the same size (assuming a normal distribution) and our module predictions, therefore, representing the probability of seeing such modules at chance.
Similar(54)
For each real module s with ns nodes, we generated the random modules by randomly selecting a set of ns nodes from the whole network.
We then obtained the distribution of each parameter for 1000 random modules that were generated by randomly selecting a set of ns nodes from the whole network.
The precision-recall plot showed significant levels of precision compared to a control in which SI was computed on random modules (Figure S6b).
Although there was the same number of nodes between a real module and corresponding random modules, there was different edge density that likely contribute to the difference in network parameters.
An empirical false-discovery rate (FDR) for the recurrence score was determined by simulating random modules of each size and defining scores with associated FDR<5% as high, FDR>95% as low, and intermediate FDR as a moderate (Figure S2a).
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