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The effect of these inaccurate alignments would be negligible when random fragments are sequenced, because the read starts and read ends are all staggered after random fragmentation.
Genomic DNA was sonicated (Bioruptor, Diagenode) to produce random fragments ranging in size from 300 to 1,000 bp and 6 µg of fragmented DNA was used for a standard MeDIP assay [38], [60].
Random fragments of the donor chromosomes are integrated into recipient chromosomes or retained as separate minichromosomes.
We would take some random fragments of my DNA, as one does all the time in sequencing the human genome.
Morioka et al. sequenced D4Z4 using the PacBio sequencer21 and analyzed random fragments from the BAC clone.
Why do our minds get uncontrollably stuck on repeat with certain random fragments of a song, symphony, or video game?
And so will we — in seemingly random fragments at first, which coalesce into something transcendent.
Ms. Luken's impressive large paintings look like they are gatherings of random fragments from nature and from the world of wizardry.
Because gene-sequencing machines can handle only small stretches of DNA, the DNA to be sequenced is broken into random fragments.
The clues, those cruelly encouraging red herrings, are just random fragments found at the scenes of Dory's chance collisions with everyday abnormal human behavior.
But, even so, it will have seemed like a collection of random fragments of activity scattered across cyberspace: some spectacular, some comical, some irrelevant.
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