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Recently, viral vector engineering involving high-throughput random diversification and selection has enabled the rapid creation of AAV vectors with valuable new gene delivery properties.
This explains the otherwise stupid practice of random diversification by which managements hoped to counter the cyclicality built into their businesses.
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In the case of phylogenetic trees, null models based on random, increasing, balanced diversification [5], [6] were only a reasonable early start.
In contrast to diversification with random mutagenesis, such as methods using epPCR, DNA shuffling exploits the recombination between genes.
In the case of drift, dialects or song variation at spatial scales could arise from a process of cultural diversification where random song mutations are produced by copy errors [ 55].
Host conservatism evolved under transient abiotic and biotic conditions in a non-random manner during the diversification of Acacia thrips.
Step 1: The diversification phase selects a random neighbor solution.
We carried out the diversification analyses on a random sample of 100 trees obtained from a relaxed molecular clock analysis, applying a pure-birth process after model selection.
We inferred the geographical origin of P. reddelli and its spatial distribution during diversification using a relaxed random walk (RRW) diffusion model across continuous space in BEAST.
Thus, the generation of the initial population is not random but a generation method based on diversification [ 36] is used to generate a set of diverse initial solutions.
Thus, HIV Gag subtypes have diversified in part because of their adaptation to the local HLA allelic frequency distributions, which contrasts with the current paradigm that HIV subtype diversification is mainly due to random founder effects (Rambaut et al., 2004).
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