Sentence examples for random breakpoints from inspiring English sources

Type I breakpoints showed significant (p<5.3×10−24) increase in homology relative to random breakpoints (52.9% vs. 40.8%).

Gene orders were simulated under the assumption that the rearrangements involve random breakpoints placed between genes.

Approximately 15% of adult background hprt mutations are due to gross structural alterations (primarily deletions) having random breakpoints; 85% result from "point" changes detected only by sequencing.

To calculate significance values for the distances obtained, the distances of breakpoints to features were compared with those measured using a set of random breakpoints.

Remarkably, when compared to the computer-generated, random breakpoints in genes, the actual breakpoints were clearly positioned very close to the RNAPII peaks detected by ChIP-seq, indicating a connection between transcription stress and genome instability in RECQL5-depleted cells.

This observed number was then tested against a null model of random breakpoints across the genome, by a binomial test where the probability of a single breakpoint being contained in a gene is the proportion of the genome covered by genes, and the number of trials in the test is the number of breakpoints in total.

Pevzner and Tesler [5] were the first to report a deviation from the "random" breakpoint model for vertebrates.

Depending upon the number of genomic regions of length 0.3 Mb available for evolutionary breakpoints, the expected number of different breakpoint regions assumed to harbour a total of 519 observed breakpoints (N = 132 in mouse, 143 in cow, 89 in opossum and 155 in chicken) was estimated under a model of random breakpoint selection in each species.

Here, our result could provide an indirect evidence for such events since if the gene conversion occurred repeatedly, the non-random breakpoints beside the two BF loci may lead to the inversion of the gene block TAP1-TAP2 bethemn them.

The distances within each randomization were ranked, and the mean value for each centile across randomized breakpoints gives the "random" number plotted – allowing an assessment of whether the observed distances are closer than expected by chance.

Two of the 3G QFP were located in the regions with prevalent 5′ or 3′ breakpoints and thus showed a high density of breakpoints within 100 bp, but not with random or partially randomized breakpoint sets.