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The former induces DSB and random break sites on DNA, whereas the latter induces SSB and only one specific break site.
In Multi-DB+, we introduce a technique called random break into Multi-DB; in Multi-DB++, we introduce a technique called random walk into Multi-DB+.
Electro-induced break junction (EIBJ) can generate an instantaneous and random break, but to obtain reproducible and stable devices it is very important to control the width of the nanogap [7, 8].
For instance, in a 300 nt transcript that is targeted by a 70mer oligonucleotide, there is nearly a one in four chance that a random break in the sequence will occur within the target site for which the probe is designed.
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The null distribution of the number of breaks with a given chromosomal feature within 6 kb was determined by randomizing the location of break sites and determining the distance between these random breaks and the chromosomal features.
"Clearly, there's a huge difference between a random break-in and, say, an ex-boyfriend breaking into an apartment to get his stuff," Mr. Holovaty says.
One event could be the textathlon, which would involve high-speed texting while skiing, with random breaks for shooting, of course.
Follow Mark on TwItter.
Thornton, who starred in "Sonny with a Chance" and "So Random!", broke the joyous news to her fans via WhoSay.
Heat-induced fragmentation of RNA introduces mostly random breaks into the phosphodiester backbone.
The matched RESs in their 500-bp-long flanking sequences were removed as random breaks [ 23].
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