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For example, raising the expression of the drug transporters, including ABC (ATP-binding cassette) drug transporters, that pump out chemotherapeutic agents is another potential mechanism, as ABC expression may be enriched for cancer stem cells [23].
We also asked whether raising the expression of ball in wild type pNBs causes an increase in the rate of pNB proliferation by over-expressing a UASp- ball transgene in wild type thoracic pNBs (Siegrist and Doe, 2005).
Other oxidants (such as H2O2) have already been shown to increase APP cleavage by raising the expression of BACE-1 and, as a consequence, to enhance the production of both Aβ42 and Aβ40 (Coma et al, 2008; Shen et al, 2008; Tamagno et al, 2002; O'Connor et al, 2008).
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Cultured ICC constructs with CSRARKQAASIKVAVSADR reduced the expression of stage-specific embryonic surface antigen-1 and raised the expression of β III tubulin of differentiating iPS cells.
"The presence of so many Alu sequences throughout the genome allows evolution to ask, What would happen if I raise the expression of Gene X threefold during development -- does that make a better primate?
FoxO1 raises the expression of 4E-BP1, a potent repressor of mRNA translation and suppressor of cell growth 59, 60.
Interestingly, the introgressed QTLs raise the expression of γ-zeins, which appear to be able to restore kernel hardness despite the reduced levels of α-zeins [ 7].
Overall, these results demonstrate that PGE2 can raise the expression of Wnt-target genes, specifically, Ctnnb1, Ptgs2, Ccnd1, and Mmp9, in WntA-induced NE-4C cells.
An important consequence of the identification of genes that are promoters or blockers is the possibility of targeting therapies in such a way that they should raise the expression of some blockers and/or lower those of some promoters.
In our study, we could show that treatment of TGCT cells with HP-compounds raised the expression of the cell cycle-inhibiting molecule p21, which resulted in an S-phase arrest of the cell cycle.
ZnCl2 was able to raise the expression of the most abundant metallothionein, Mt2, in hypoxic ZnT8−/− mouse islets to levels similar to those of hypoxic WT islets (Fig. 6g).
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