A 2009 World Bank study found that raising mobile-phone penetration in a developing country by ten percentage points increased GDP growth by 0.8% a year.
That is a pricey 21 times cash flow, and producing a payoff will require raising the rate of penetration.
Interestingly, some MAbs can transiently reverse blockage of acetylcholine release when microinjected inside ganglionic neurons (21), raising the possibility that antibodies engineered for enhanced cellular penetration may have superior therapeutic properties.
The integration of these resources has positive impact from environmental perspective but their penetration has raised serious issues on secure and reliable operation of a network, owing to their intermittent and not dispatchable output.
Concerns have also been raised about the poor penetration of beta-lactams into macrophages, the site where B. anthracis spores germinate.
Alumina dissolution is triggered by the penetration of the solution via cracks/pinholes through the coating to the substrate surface where oxygen reduction takes place, raising the pH.
Here, we address the hypotheses that raising endosomal pH with the modifying agents chloroquine, omeprazole or bafilomycin A might decrease sequestration of anticancer drugs in endosomes, thereby increasing their cytotoxicity and availability for tissue penetration.
Cell penetrating peptides raise new promises for the controlled cell-specific penetration of peptides (10).
This is consistent with a primarily intercellular colonization pattern of host apical meristems [ 81], though it raises questions about how appressorium penetration is accomplished.
Testing drugs in a 3D culture model raises the issue of drug penetration, which may be impaired by structural features of the three dimensional culture, including the size of the spheroids [ 24].
