"O.K., then, raise the dose, and see how you do," she said agreeably.
I told her it felt as if I needed to raise the dose.
We can also use an iterative treatment approach (as Socolow proposed), starting some treatments and monitoring their effects and side effects before raising the dose.
Now, many doctors may decide to give the other drugs a try, or raise the dose of Zocor.
Raising the dose of cholesterol-lowering drugs could prevent many more heart attacks and strokes, say researchers.
However, the study authors warned that simply raising the dose of the most commonly-used statin in the UK, simvastatin, the version available direct from pharmacies, might be counterproductive.
"Zetia alone causes no liver or muscle enzyme elevations in recent trials, but enzyme elevations on Zetia plus statins suggest that adding Zetia to statin therapy isn't necessarily a safer way to hit a particular LDL level than simply raising the dose of the patient's statin," Evans wrote.
The dose-effect relationship is the effects of progressive elevation of serotonin, either by raising the dose of one drug, or combining it with another serotonergic drug which may produce large elevations in serotonin levels.
Raising the dose to 2 mg/kg diminished the response so that it became non-significant.
Raising the dose to 0.1 mg/kg produced statistically significant inhibition that was still only 5 15%.
