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This raises a significant problem for mechanistic modeling, since in the absence of objective measures of database bias or reliability it is not clear which genes/proteins to include for modeling or experimental measurement.
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The failure of mammography to recognize DCIS or EIC in radiologically dense breasts in young populations raises a significant problem.
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This creates a significant problem for the government.
"Falluja has been a problem, a significant problem for the coalition and for Iraqi security forces for many, many months".
Eat It Later posed a significant problem for me.
This was recognised as a significant problem for some clinicians.
ClinicalTrials.Gov NCT00393055 Dental caries is a significant problem for adults.
Pain is a significant problem for patients with KOA [ 31].
Lackey (2008) and Schmitt (2010) raise an important problem for the assurance view.
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