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It has raised fourfold the subsidy to Matica slovenska, a nationalist cultural outfit that condemns the execution in 1947 of Father Jozef Tiso, the wartime puppet state's priest-president.
The global buildup of heat-trapping emissions from smokestacks and tailpipes appears to have at least doubled, and probably raised fourfold, the chances that Europe will be struck by an extremely hot summer like the one that caused more than 20,000 premature deaths last year, scientists reported.
In order to test this conjecture, the glucokinase level is raised fourfold after the insulin failure is detected.
If the glucokinase level in the unhealthy cells is raised fourfold and then kept unchanged during the simulation, the total insulin secretion becomes normal (see Additional file 5: Figure 8).
However, in order to minimize the amount of blood to be withdrawn from the patients, the volume of plasma to be extracted prior to the chromatographic analysis from each sample was divided by 4. As a consequence, the limits of quantification were raised fourfold to 4 and 8 ng ml−1 for bosentan and its metabolites, respectively.
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In obese patients with type 2 diabetes and a baseline HbA1c ranging from 6.8%7.3%%, GLP-1 plasma concentrations were raised up to fourfold during meal tests with linagliptin administration in a randomized, double-blind, placebo-controlled trial.
In India with the arrival of high yielding varieties, addition of macronutrients such as N, P and K fertilizers raised productivity by fourfolds, which in turn, however, led to deficiency of micronutrients in most of the soil (Singh 2008).
BLOOMBERG NEWS Buyout Firms Flockck to Indonesia | Private equity firms focused on Indonesia have increased their fund-raising about fourfold from 2010, according to the Center for Asia Private Equity Research in Hong Kong, Bloomberg News reports.
Animals were given 1800 anti-factor X units/kg of LMWH, which raised the primary bleeding time approximately fourfold.
The secondary amine was obtained under harsh base conditions using NaOH, whereby the substituted benzyl group was introduced in a microwave-assisted aqueous N-alkylation.[ 16] Surprisingly, the employment of four equivalents of Li base was not sufficient for the lithiation of pyridine 4 a (59 % yield); increasing amounts of the base raised the yield of chloride 4 b fourfold to 78%%.
After mining her Ivy League and law-firm contacts, though, she raised $1.77 million, eclipsing her nearest rival more than fourfold, and trounced a field of better-known competitors, including a county commissioner and the son of a former congressman.
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