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Furthermore, NADPH oxidase activity was significantly increased, with raised expression of NOX1, NOX2, NOX4, p38MAPK and MnSOD, in the renal tissue of hyperoxaluric rats compared to control.
This change in phenotype is characterized by a raised expression of type I collagen and a decrease in type II collagen expression.
Then, the raised expression of musclin could lead the hypertension to be more serious.
In hormone-dependent tumours, Gd has been described to have various effects through reduced expression of oncogens and raised expression of tumour suppressor genes.
Thirdly, where hepcidin levels are raised, expression of the iron transport protein ferroportin in enterocytes is suppressed such that release of absorbed iron into the bloodstream is restricted.
Our results show that most (eight out of nine) synovial sarcomas clustered as a single group based on their gene expression portrait and that this cluster was characterised by the raised expression of a set of 48 genes.
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Various classes of polyphenols have been shown to post-transcriptionally regulate levels of mRNA containing AU-rich elements by raising expression of RNA binding proteins [ 46– 46].
Specifically, daidzein raises expression of BRF2 and BRF1 in MCF-7 cells, as well as pol III transcripts that depend on these TFIIIB subunits for their synthesis.
Additionally, given the gain-of-function behavior of the Malaysian allele of AFT1, it is tempting to speculate that negative regulatory control of this activator of the iron starvation response has been eliminated in Malaysian yeast to sidestep iron-sensing mechanisms and raise expression of iron transporters and scavengers as would be suitable for a constant, low-iron environment.
What had appeared to be a pretty healthy, diversified gut was now raising expressions of concern among the microbiologists who looked at my data.
However, concerns remain regarding the translation of these models to human SOD1-fALS particularly becauSOD1-fALS particularlyverexpressed in transgenics and such raised expression levels affect the pathology of these animals (6, 12).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com