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Observation of stellae novae and comets condemned the crystalline spheres and raised doubts regarding the doctrine of the immutability of heavens.
Besides questioning the validity of species trees, these findings have raised doubts regarding the possible sources for the high topological variability and the implications for large-scale phylogenetic inferences such as the prediction of orthology relationships.
However, the persistence of viable bacteria in dentin after these techniques has raised doubts regarding the long-term effectiveness of treatment [ 31].
Thus, although TF-FVIIa and FXa can activate PAR2 and PAR1 plus PAR2, respectively, relatively high concentrations are required, which has raised doubts regarding the biologic relevance of signaling by these upstream coagulation proteases.
However, several authors have raised doubts regarding the real prognostic value of H.Pylori status, suggesting that H.Pylori negativity may be simply related to more advanced tumor progression [ 37, 38].
A few years ago, a couple of articles in Lancet [ 2, 3] raised doubts regarding the validity of the majority of these trials and led to a relevant public debate.
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Conversely, dissimilar expression reported for nk2.1 and hnf6 in the apical plate of sea urchins and the episphere of abalone larvae [ 24] raised doubt regarding the common origin of similar shared larval features.
CtW says it is yet to hear back from Tesco, a delay which it claims has "undermined shareholders' ability to vote on this amendment by proxy, and also raises doubts regarding voting at the agm itself".
There is a recent and growing research literature on alcohol use and related harms among transgender and other gender minority populations; however, current definitions and measures of hazardous drinking do not consider the complexity of physiological sex characteristics and socially constructed gender, raising doubts regarding their validity, applicability, and use with these populations.
The fact that doubts and disagreements can arise regarding acquaintance or the given should not be too puzzling since not everything about the nature of the given is itself given, and, as Descartes observed long ago, one can easily raise doubts regarding what one can see most clearly and distinctly, at least while one is not attending directly to the appropriate ground or insight.
The fact that BnsD and BnsG are upregulated during growth on naphthalene leaves open the possibility that methylation is used to activate naphthalene in NaphS2, however as mentioned previously, the conflicting observation that NmsABC was not upregulated during growth on naphthalene in our experiment and previous experiments raises doubts regarding that hypothesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com