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"The presence of so many Alu sequences throughout the genome allows evolution to ask, What would happen if I raise the expression of Gene X threefold during development -- does that make a better primate?
Interestingly, the introgressed QTLs raise the expression of γ-zeins, which appear to be able to restore kernel hardness despite the reduced levels of α-zeins [ 7].
Overall, these results demonstrate that PGE2 can raise the expression of Wnt-target genes, specifically, Ctnnb1, Ptgs2, Ccnd1, and Mmp9, in WntA-induced NE-4C cells.
ZnCl2 was able to raise the expression of the most abundant metallothionein, Mt2, in hypoxic ZnT8−/− mouse islets to levels similar to those of hypoxic WT islets (Fig. 6g).
An important consequence of the identification of genes that are promoters or blockers is the possibility of targeting therapies in such a way that they should raise the expression of some blockers and/or lower those of some promoters.
Elevated glucose in human endothelial cells also can raise the expression of antioxidants that include superoxide-dismutase, catalase, and glutathione peroxidase, illustrating that vascular cells may attempt to initially negate the effects of oxidant stress injury [ 67].
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Cultured ICC constructs with CSRARKQAASIKVAVSADR reduced the expression of stage-specific embryonic surface antigen-1 and raised the expression of β III tubulin of differentiating iPS cells.
FoxO1 raises the expression of 4E-BP1, a potent repressor of mRNA translation and suppressor of cell growth 59, 60.
For example, raising the expression of the drug transporters, including ABC (ATP-binding cassette) drug transporters, that pump out chemotherapeutic agents is another potential mechanism, as ABC expression may be enriched for cancer stem cells [23].
In our study, we could show that treatment of TGCT cells with HP-compounds raised the expression of the cell cycle-inhibiting molecule p21, which resulted in an S-phase arrest of the cell cycle.
We also asked whether raising the expression of ball in wild type pNBs causes an increase in the rate of pNB proliferation by over-expressing a UASp- ball transgene in wild type thoracic pNBs (Siegrist and Doe, 2005).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com