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"O.K., then, raise the dose, and see how you do," she said agreeably.
I told her it felt as if I needed to raise the dose.
Now, many doctors may decide to give the other drugs a try, or raise the dose of Zocor.
Importantly, the present study addresses the necessity not to raise the dose of monoHER above the presently used 1500 mg m−2 to avoid apoptosis-protecting concentrations which might adversely affect the antitumour activity of DOX.
These strategies consisted in: a) to start the new antipsychotic and raise the dose to therapeutic levels, while gradually lowering the dose of previous antipsychotic, and b) to instate a washout period before starting the new antipsychotic [ 49].
Because most patients who respond to a SRI do so at a mean dose considerably lower than the maximum, an aggressive forced titration strategy to raise the dose to the "maximum tolerated therapeutic dose" independent of response status was deemed unwarranted clinically, as it could impose an undue experimental and adverse event burden on patients.
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We can also use an iterative treatment approach (as Socolow proposed), starting some treatments and monitoring their effects and side effects before raising the dose.
Raising the dose of cholesterol-lowering drugs could prevent many more heart attacks and strokes, say researchers.
However, the study authors warned that simply raising the dose of the most commonly-used statin in the UK, simvastatin, the version available direct from pharmacies, might be counterproductive.
"Zetia alone causes no liver or muscle enzyme elevations in recent trials, but enzyme elevations on Zetia plus statins suggest that adding Zetia to statin therapy isn't necessarily a safer way to hit a particular LDL level than simply raising the dose of the patient's statin," Evans wrote.
The dose-effect relationship is the effects of progressive elevation of serotonin, either by raising the dose of one drug, or combining it with another serotonergic drug which may produce large elevations in serotonin levels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com