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This environmental stress can potentially raise susceptibility to diseases such as chytridiomycosis, and thus lead to amphibian declines.
Alternatively, immune activation due to virus exposure during PrEP could raise susceptibility to HIV infection by recruiting activated, HIV-specific CD4+ target cells to mucosal surfaces, thus potentially facilitating infection during subsequent exposures [7], [8] or increasing replication after virus transmission [7], [9].
(A possible shortcut to such a lengthy program could be to use the sequencing data accumulated in the search for alleles that raise susceptibility and look for polymorphisms in human HSF1 that are rare in old people who have had cancer).
This large, well-characterized dataset of relative pairs and multiplex epilepsy families provides an unparalleled opportunity for genetic analysis, both to detect clinically defined syndromes that have not previously been recognized, and to identify genomic variants that raise susceptibility to these specific syndromes.
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It leads to the disabling of brain cells, which raises susceptibility to neurodegenerative disease.
Biologically, fear produces chronic stress, which increases blood pressure and raises the risk of cardiovascular disease, suppresses the immune system and raises susceptibility to and severity of infectious disease, increases the likelihood of Type 2 diabetes, suppresses growth, memory, and fertility.
Conversely, knockdown of PRDX-3 leads to raised susceptibility to oxidative stress.
Deletion of the Tip30 gene increased proportion of mammary stem and progenitor cell populations, and raised susceptibility to ER+ mammary luminal tumors in female Balb/c mice.
This suggests that breast duct development may be a period of raised susceptibility to breast carcinogenesis, and that the association between puberty and breast cancer is complex and not best represented by a single event.
Nevertheless, prior or current smoking history in HIV-infected persons raises susceptibility to several lung diseases that occur concurrently or in sequence, including tuberculosis, recurrent bacterial pneumonia, COPD, and influenza.
The high risks for women irradiated at young ages (Hancock et al, 1993; Bhatia et al, 1996; Mauch et al, 1996; Sankila et al, 1996; Aisenberg et al, 1997; Metayer et al, 2000; De Bruin et al, 2009; Swerdlow et al, 2012) imply that puberty might be a time of raised susceptibility.
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