These studies also reveal substantial differential expression between lineages (Table 3), with ~26% of expressed genes showing significant differences in at least one strain (although the high percentage of differentially expressed genes may simply reflect the low variance among biological replicates, which raises statistical power to detect subtle changes in expression levels).
Another limitation is related to the simplification of variables that has been realized to raise the statistical power of the study.
Therefore, we decided to analyze them together to raise the statistical power for analyzing the exposures in question.
Therefore, the exclusion of W lineages raised issues about statistical power, but the magnitude of the relationships of interest remained unaffected.
Criticisms of each of the individual studies were raised, including inadequate statistical power and the use of various degrees of glucose control, all lower in the subsequent trials [ 3- 7] than in the initial Leuven I study [ 2].
Although it would raise a reduction of statistical power, the significant associations were still observed in the primary analyses.
The weakness of the congruency effect in the determiner-noun condition raises doubts about the statistical power of the experiment in general, which may also account for the seeming absence of a gender-congruency effect in bare noun production.
We thank the reviewers for raising the important issue of statistical power and sample size.
First, the small number of cases after some subsets stratification raises concern with regards to statistical power.
However, all three studies observed a non-significant trend towards a benefit with preoperative ACEi/ARB use raising the possibility of insufficient statistical power to detect the association [ 37, 44, 45].
Another limitation is the lack of HbA1c results for the majority of the sample, which limited statistical power and raises the concern that this portion of the sample may be different in important ways from the participants who were unable to provide an HbA1c value.
