But doctors may also have been reluctant to raise doses because of the risk of serious side effects like muscle pain, weakness and increased blood sugar levels.
Sites which appear to have a raised dose response are then analysed by the bootstrap and the distribution of LRT is estimated by simulation.
Because most patients who respond to a SRI do so at a mean dose considerably lower than the maximum, an aggressive forced titration strategy to raise the dose to the "maximum tolerated therapeutic dose" independent of response status was deemed unwarranted clinically, as it could impose an undue experimental and adverse event burden on patients.
These strategies consisted in: a) to start the new antipsychotic and raise the dose to therapeutic levels, while gradually lowering the dose of previous antipsychotic, and b) to instate a washout period before starting the new antipsychotic [ 49].
"O.K., then, raise the dose, and see how you do," she said agreeably.
I told her it felt as if I needed to raise the dose.
Now, many doctors may decide to give the other drugs a try, or raise the dose of Zocor.
Importantly, the present study addresses the necessity not to raise the dose of monoHER above the presently used 1500 mg m−2 to avoid apoptosis-protecting concentrations which might adversely affect the antitumour activity of DOX.
We tried to replicate the dose escalation in Figure 2a of the ref. 24 by raising the dose in patients who had the lowest drug concentration at designated time points.
For diazinon, doses of 0.5, 1, or 2 mg/kg had no effect on survival; raising the dose to 5 mg/kg resulted in the loss of < 10% of the neonates, an effect that did not achieve statistical significance but was obviously nearing the maximum tolerated dose.
