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Not only posing a challenge for ranking identified peptides within a single experiment, this also raise a serious problem when one wishes to compare or combine search results from different scoring functions (or search methods).
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This raises a serious problem for the one-name-one-thing view.
Reacting to Stone's proposal, Joel Feinberg (1974) raised a serious problem.
In Part 2 of the "Conclusion" of the Enquiry, Hume raises a serious problem with his account of justice.
This admission raised a serious problem for the formulation of a meaning criterion: how was one to rule out unwanted metaphysical claims while admitting as significant highly abstract scientific claims?
Clarke's view raises a serious problem for Newtonians: if action at a distance is simply a contradiction, and therefore not a possible physical situation, even with divine intervention, then how ought one to interpret the theory of universal gravity, which certainly appears to indicate that distant action is perfectly possible, and perhaps even actual?
For not only can the argument from evil be formulated in terms of specific evils, but that is the natural way to do so, given that it is only certain types of evils that are generally viewed as raising a serious problem with respect to the rationality of belief in God.
It raises a serious problem, a real danger, but it is very deceptive.
A statute permitting indefinite detention of an alien would raise a serious constitutional problem.
In parts of the south, the unreliability of rainfall combines with its relative scarcity to raise a serious aridity problem.
But as the number of nodes in a multiprocessor increases, the probability of encountering failures in one or more nodes of the system raises as a serious problem.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com