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Independence of S100A1-mediated signaling from RAGE might further contribute to differential activation of intracellular pathways, although in vivo involvement of RAGE through heterodimerization of S100A1 with RAGE ligands (e.g., S100B) and TLR-mediated RAGE assembly cannot be ruled out categorically.
Being identified as a ligand for RAGE [ 10], MRP8/14 is believed to facilitate the detrimental effects of RAGE through advanced end glycation products [ 11].
"Channel rage through intermediaries".
Tucker would rage through the anonymous government department, DoSAC, attacking its ministers.
Hurricanes sweep regularly through the American South and wildfires rage through much of the West.
IN A confetti of medicines, pens and second-hand shirts, armed looters rage through Bunia's main market-place.
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A fierce battle raged through much of the night, until 7 a.m.
The fire that raged through Notre Dame has made us all look at this great cathedral differently.
But the fire raged through 100 acres of saltwater and fresh spring-fed wetlands, which were at low tide.
"War was raging through Japan at the time," Ms. Wong said.
The fires raging through Southern California are ferocious and fast.
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