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RAFT polymerisation facilitated the synthesis of semitelechelic copolymers, which were used in the synthesis of monoclonal anti-CD20 antibody polymer drug conjugate designed for cell-specific tumour targeting.
Herein, we describe a novel photo-initiated RAFT polymerisation procedure, using a tubular continuous flow reactor for the polymerisation of (meth)acrylates and acrylamides at close to ambient temperatures.
With the advent of controlled radical polymerisation (CRP) techniques – such as RAFT polymerisation and ATRP – new families of well-defined polymers with narrow molecular weight distribution and predictable molecular architecture potentially suitable to generate siRNA delivery devices are becoming available.
In this paper, we have designed and synthesized well-defined pegylated-polymers with tertiary amines from readily available commodity monomers 2- dimethylamino)ethyl methacrylate (DMAEMA) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA, Mn ∼ 475 Da) by reversible addition–fragmentation chain transfer (RAFT) polymerisation.
12302_2018_143_MOESM1_ESM.pdf Additional file 1. RAFT polymerisation.
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Classically, RAFT polymerisations are conducted in batch using thermal initiators.
RAFT polymerization and surface-initiated RAFT polymerization (SI-RAFT) of chloroprene was studied.
TEMPO (2,2,6,6-tetramethylpiperidinyl-1-oxy) mediated and RAFT (reversible addition fragmentation chain transfer) living free radical polymerisation are some of the techniques used for the synthesis of block copolymers [17 19].
New chain transfer agents for free radical polymerisation via reversible addition-fragmentation chain transfer (RAFT) were synthesised that are particularly suited for aqueous solution polymerisation.
The RAFT (Reversible Addition–Fragmentation Chain Transfer) approach allows for greatly enhanced control over radical polymerisation processes, resulting in polymers with low dispersity.
The RAFT (Reversible Addition-Fragmentation Chain Transfer) process greatly enhances the control over radical polymerisations, while leaving behind a thiocarbonylthio end-group.
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