Exact(4)
FcεRI has been reported to translocate into lipid rafts upon Ag stimulation [24] [26], [28], and the implication of a lipid raft environment in regulating the Ag-induced FcεRI ubiquitination has also been envisaged [30].
We demonstrate that ubiquitinated receptor accumulate into lipid rafts within minutes after their engagement and that receptor ubiquitination is altered by cholesterol depletion (Figures 4 and 5A), arguing in favour of a role for a lipid raft environment in the initiation of receptor ubiquitination.
Our data suggest that raft environment is essential for Ser473 Akt phosphorylation in MCL cells.
Eventually, it is retained with a glycosyl-phosphatidylinositol anchor in an extracellular lipid raft environment of the cell membrane (Stahl et al., 1987).
Similar(56)
Linked through their basic roles in lipid biology, ApoE genotype could greatly influence omega-3 PUFA concentrations, transport, metabolism, and sequestration in lipid raft environments essential for healthy neuronal function and synaptic maintenance.
Rafts in lipid bilayers are defined as liquid-ordered (lo) phases in a liquid-disordered (ld) non-raft environment [33].
Based on studies of model membranes, lipid rafts are defined as liquid-ordered (lo) membrane phases coexisting with a liquid-disordered (ld) phase of the non-raft environment in the lipid bilayers [10].
Although BACE1 can process APP in both raft and non-raft environments, a membrane-anchored version of a BACE1 transition-state inhibitor produced by linkage to a sterol moiety appeared more potent as a result of targeting to lipid rafts [ 23].
They want to legalise marijuana, pass an equal pay law, increase the refugee quota, bring Te Reo into schools, and introduce a raft of environment protection measures.
Later data collectively demonstrate that modified raft lipid environment affects the membrane subdomain distribution of proteins involved in the interleukin-2 receptor (IL-2R) and toll-like receptor (TLR-4) signaling pathway [ 123, 124].
In contrast to rafts isolated in a detergent-free environment, lipid rafts isolated in the presence of detergent from co-cultures of YH16.33 and A20 cells in presence or absence of specific antigen showed a higher frequency of macrodomains, some of which were up to micrometers in size.
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