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In recent years, a lot of new chemotherapeutic drugs have been approved and radiotherapy technology is increasingly more mature.
Experts say the UK is lagging behind the US and Europe in introducing new, more targeted radiotherapy technology, such as intensity modulated radiotherapy (IMRT) or image guided radiotherapy (IGRT).
Since then, aligned with the advances in radiotherapy technology and techniques (e.g. four-dimensional computed tomography simulation and image-guided radiotherapy), there has been a rapid increase in the use of lung SABR for both early stage lung cancer and lung metastases.
Moreover, the vast majority of previous studies employed conventional radiotherapy technology.
Recent advances in radiotherapy technology have provided precise radiation dose delivery to tumor site while avoiding normal liver irradiation [ 4].
This will define a more individualised treatment approach that will complement ongoing developments in brain imaging, neurosurgical and radiotherapy technology.
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Here, we propose an algorithm for evaluation of the clinical and cost effectiveness of novel radiotherapy technologies.
High investment costs and modifications over time make evaluation of novel radiotherapy technologies in clinical trials more complex.
Evolving radiotherapy technologies, such as 4-dimensional image-based motion management, daily on-board imaging, and adaptive radiotherapy, have enabled us to improve the therapeutic index of radiation therapy for lung cancer by permitting the design of personalized treatments that deliver adequate doses conforming to the target while sparing the surrounding critical normal tissues.
Inside small field sizes, for instance 1×1 and 2×2 cm2, that have a typical area of a beam segment used in new radiotherapy technologies, such as the intensity modulated radiation therapy, it takes place the lateral electronic disequilibrium, which is not correctly modelled by the correction algorithms used by the planning system.
Furthermore, whether these newer radiotherapy technologies will necessarily reduce second cancer risks is also not clear.
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