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Therefore, rather than discarding potential new drug combinations with radiotherapy, information regarding the possibility for unacceptable toxicities is needed and should be widely accessible to the cancer community prior to the initiation of clinical trials.
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Unfortunately, such information is not available through the R & V system; obtaining such information requires linking radiotherapy data to other data sources.
This CD ROM includes three example cases, each of which consists of a clinical summary, CT slice data, outlines and Radiotherapy plan information.
At the time of first sampling, four (21%) received chemotherapy, three (16%) had radiotherapy and information on treatment was not available in the rest.
To assure quality control of radiotherapy, planning information, simulator films and dose distributions, including dose volume histograms, and a copy of the treatment prescription were made available for central review.
The timing of SPECT/CT scans is intended to reveal i) acute and sub acute changes in total kidney function (GFR measurement) before and following radiotherapy, ii) information on kidney positioning before and following radiotherapy, and iii) the time-dependence of changes in regional kidney function and position (SPECT/CT scans) before and following treatment.
We did not have access to chemotherapy and radiotherapy dose information within this study; this has recently been addressed by others for survivors of childhood cancer (Mulrooney et al, 2009; Tukenova et al, 2010; Blanco et al, 2012; van der Pal et al, 2012); however, more comprehensive studies using accurate treatment data are still required.
Halkett et al 11 mapped the specific radiotherapy-related information that patients desire and demonstrated that information needs peak at the time of treatment planning and again prior to treatment.
There are survival outcome reports for small cohorts of patients receiving temozolomide with radiotherapy, but this information is not sufficient to support firm recommendations.
28 31 We were unable to distinguish between the impact of preoperative and postoperative radiotherapy, because this information was not systematically available, but fewer patients received radiotherapy in Europe than in the USA and the practice in Europe was strikingly heterogeneous, even within a given country.
Data on late effects of radiotherapy as well as information on demographic and epidemiological factors were available for 421 breast cancer patients, as reported earlier (Lilla et al, 2007; Kuptsova et al, 2008).
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