Sentence examples for radiotherapy damage from inspiring English sources
Most cytotoxic drugs, and radiotherapy, damage tumour cell DNA to induce arrest in G1 or apoptosis [ 5, 6].
The Bcl-2 family of proteins play an important part in a cell's ability to undergo apoptosis following radiotherapy damage (Gudkov and Komarova 2003).
However, this treatment generates resistance and toxicity, either by the side effects caused by cisplatin (neurotoxicity, myelotoxicity, nephrotoxicity and ototoxicity) or the side effects caused by radiotherapy (damage to the normal tissue).
Radiation toxicity can sometimes be very difficult to ascertain in patients with GBM for two reasons: the short median survival is probably not long enough for late radiotherapy toxicity to become apparent in many of these patients; and these tumors are associated with large areas of necrosis, which may be mistaken for radiotherapy damage on imaging studies.
Radiotherapy damages tissue because energy dissipated from ionising radiation generates a series of biochemical events inside the cell.
Radiotherapy damages DNA directly and causes double‐strand breaks (DSB) that are considered as the main lethal form of DNA damage caused by ionizing radiation (IR).
The cancer therapy itself, including chemotherapy or radiotherapy, damages healthy cells throughout the body, resulting in side-effects including nausea, emesis, decreased nutritional intake and anaemia.
However, it is common for patients with cancer to have pain, fatigue, and skin reactions when receiving radiotherapy because of radiation damage to the adjacent normal tissues.
Potential mechanisms of chemotherapy and radiotherapy interactions include increasing radiation damage, inhibition of DNA repair processes, enhanced activity against hypoxic and radioresistant cells, and prevention of regrowth of tumour after radiation [ 63].
We show that bystander responses play a major role in mediating radiation damage to cells at low-doses of radiotherapy, doing more damage than that due to direct radiation.
However, radiation damage remains a major negative consequence of radiotherapy.
